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Osteopontin Rabbit anti-Human, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 22952-1-AP-20UL
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Description
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.Specifications
| Osteopontin | |
| Polyclonal | |
| Unconjugated | |
| SPP1 | |
| BNSP, Bone sialoprotein 1, BSPI, ETA 1, Nephropontin, OPN, Osteopontin, secreted phosphoprotein 1, SPP 1, SPP1, Urinary stone protein, Uropontin | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 25353, 6696 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Western Blot | |
| 0.36 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P08721, P10451 | |
| SPP1 | |
| Osteopontin Fusion Protein Ag19216 | |
| 20 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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