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Thermo Scientific Chemicals Chloroquine diphosphate salt, 98%
Chloroquine diphosphate salt, CAS # 50-63-5, is a member of the quinolone family that is considered to be a DNA intercalator. It shows anti-malarial, anti-inflammatory, and anti-filaricides activities.
49.95 € - 379.89 €
Chemical Identifiers
| CAS | 50-63-5 |
|---|---|
| Molecular Formula | C18H32ClN3O8P2 |
| Molecular Weight (g/mol) | 515.86 |
| MDL Number | MFCD00069852 |
| InChI Key | QKICWELGRMTQCR-UHFFFAOYNA-N |
| Synonym | chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine |
| PubChem CID | 64927 |
| IUPAC Name | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid |
| SMILES | OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15368865
|
Thermo Scientific Chemicals
455240250 |
25 g |
49.95 €
25g |
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|
15384998
|
Thermo Scientific Chemicals
455241000 |
100 g |
164.00 €
100g |
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|
15394998
|
Thermo Scientific Chemicals
455245000 |
500 g |
379.89 €
500g |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action
Applications
• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens
• This compound shows anti-malarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM
• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
• Chloroquine diphosphate salt has been used in autophagy inhibition studies
Chemical Identifiers
| 50-63-5 | |
| 515.86 | |
| QKICWELGRMTQCR-UHFFFAOYNA-N | |
| 64927 | |
| OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1 |
| C18H32ClN3O8P2 | |
| MFCD00069852 | |
| chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine | |
| 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid |
Specifications
| 50-63-5 | |
| 2% max. (105°C, 16 h) | |
| 97.5% min. (HPLC) | |
| MFCD00069852 | |
| Solubility in water: 50g/L. Other solubilities: insoluble in alcohol, benzene, chloroform, ether | |
| OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1 | |
| 515.86 | |
| 515.86 | |
| Chloroquine diphosphate salt |
| 200.0°C | |
| Authentic | |
| C18H32ClN3O8P2 | |
| chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine | |
| QKICWELGRMTQCR-UHFFFAOYNA-N | |
| 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid | |
| 64927 | |
| 98% |
Safety and Handling
GHS H Statement
Harmful if swallowed.
GHS P Statement
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
GHS Signal Word: Warning
missing translation for 'einecsNumber' : 200-055-2
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
- Chloroquine diphosphate salt
Signal Word
- Warning
Hazard Category
- Acute toxicity Category 4
Hazard Statement
- H302-Harmful if swallowed.
Precautionary Statement
- P264-Wash thoroughly after handling.
- P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
RUO – Research Use Only