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  7. Thermo Scientific Chemicals Chloroquine diphosphate salt, 98%

Thermo Scientific Chemicals Chloroquine diphosphate salt, 98%

Product Code. 15394998
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Quantity:
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500 g
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Description

Chloroquine diphosphate salt, CAS # 50-63-5, is a member of the quinolone family that is considered to be a DNA intercalator. It shows anti-malarial, anti-inflammatory, and anti-filaricides activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information


• Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action


Applications

• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens
• This compound shows anti-malarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM
• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
• Chloroquine diphosphate salt has been used in autophagy inhibition studies

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-63-5
Molecular Formula C18H32ClN3O8P2
Molecular Weight (g/mol) 515.86
MDL Number MFCD00069852
InChI Key QKICWELGRMTQCR-UHFFFAOYNA-N
Synonym chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
PubChem CID 64927
IUPAC Name 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
SMILES OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1

Specifications

Melting Point 200.0°C
Loss on Drying 2% max. (105°C, 16 h)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Quantity 500 g
Solubility Information Solubility in water: 50g/L. Other solubilities: insoluble in alcohol, benzene, chloroform, ether
Formula Weight 515.86
Percent Purity 98%
Chemical Name or Material Chloroquine diphosphate salt

Safety and Handling

compliance-icons
Product Identifier
  • Chloroquine diphosphate salt
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
 Hazard Statement
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P264-Wash thoroughly after handling.
  • P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.

RUO – Research Use Only

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