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Thermo Scientific™ BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)
Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.
264.00 € - 371.00 €
Specifications
| Chemical Reactivity | Amine-Amine |
|---|---|
| Cleavable | No |
| Description | BS(PEG)5 |
| Molecular Weight (g/mol) | 532.5 |
| PEGylated | Yes |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15930463
|
Thermo Scientific™
A35396 |
10 x 1 mg |
264.00 €
Pack of 10 |
In Stock
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|
11821245
|
Thermo Scientific™
21581 |
100 mg |
371.00 €
100mg |
Estimated Shipment: 02-01-2025
Log in to see stock. |
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Description
Thermo Scientific™ Pierce BS(PEG)n Crosslinkers include BS(PEG)5 and BS(PEG)9, which are bis-succinimide ester-activated PEG compounds for crosslinking between primary amines in proteins and other molecules.
BS(PEG)5 is a bis-succinimide ester-activated PEG compound used for crosslinking between primary amines (—NH2) in proteins and other molecules. The N-hydroxysuccinimide ester (NHS) groups at either end of the PEG5 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds.
Thermo Scientific No-Weigh products are specialty reagents provided in a pre-aliquoted format. The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. The format enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents and reducing concerns over reagent stability.
Features of BS(PEG)5:
- Reactive groups: NHS ester (both ends)
- Reactive towards: amino groups (primary amines)
- NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds
- Water-soluble; compare to non-pegylated BS3 (also soluble) (Cat. No. 21580) and DSS (water-insoluble) (Cat. No. 21655)
- Membrane-impermeable, allowing for cell surface labeling
- Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
- Polyethylene glycol spacer arms help maintain conjugate solubility
- Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
- PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Ideal for small molecule or peptide conjugations
Alternative Names for BS(PEG)n:
- Bis-NHS-dPEG
- NHS-PEG-NHS
- BS(PEO)5
- Bis(NHS)PEO5
- BS-PEO9
- dPEG NHS ester
- Bis-succinimide ester PEG 400
Product References
- Crosslinker Application Guide -- search for recent literature references for this product
- Bioconjugate Techniques, Academic Press (Cat. No. 20036)
Related Products
- BS(PEG)9 (PEGylated bis(sulfosuccinimidyl)suberate) (Cat. No. 21582)
- BS3 (bis(sulfosuccinimidyl)suberate) (Cat. No. 21580)
Specifications
| Amine-Amine | |
| BS(PEG)5 | |
| Yes | |
| Upon receipt store desiccated at -20°C. | |
| Chemical Labeling | |
| NHS Ester | |
| Water | |
| Yes |
| No | |
| 532.5 | |
| 21.7 Å | |
| No | |
| Homobifunctional | |
| Medium (10 to 30 Å) | |
| Standard, Single-use | |
| Crosslinker |
For Research Use Only. Not for use in diagnostic procedures.
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