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PHLPP Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

145.00 € - 410.00 €

Specifications

Antigen PHLPP
Concentration 0.57 mg/mL
Applications Immunocytochemistry, Immunoprecipitation, Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16822095
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Proteintech
22789-1-AP-20UL
20 μL
145.00 €
20µL
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16812095
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Proteintech
22789-1-AP-150UL
150 μL
410.00 €
150µL
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Description

Description

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Specifications

Specifications

PHLPP
Immunocytochemistry, Immunoprecipitation, Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin)
Unconjugated
Rabbit
Human, Mouse
O60346, Q8CHE4
23239, 98432
PHLPP Fusion Protein Ag18794
Primary
-20°C
PHLPP1
0.57 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP
Phlpp1
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

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