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  6. Thermo Scientific Chemicals Ouabain octahydrate, 96%

Thermo Scientific Chemicals Ouabain octahydrate, 96%

Product Code. 10165353
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Quantity:
250 mg
1 g
5 g
25 g
Packaging:
Glass bottle
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Ouabain octahydrate, CAS # 11018-89-6, (synonym: gamma-Strophanthin), is a plant-derived organic compound that inhibits the Na+/K+ ATPase pump present in all animal cell membranes.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Ouabain octahydrate is a water-soluble, light-sensitive powder that is stable at ambient temperatures
• It is a glycoside comprised of rhamnose and ouabagenin, and is derived from the ripe seeds of Strophanthus gratus and the bark of Acokanthera ouabaio

Applications

• Ouabain octahydrate works by binding the Na+/K+ ATPase pump, thus disrupting its function, and leading to an increase in intracellular Na+.
• The inhibitory action of ouabain octahydrate on the Na+/K+ pump in cardiac cells makes it a pharmaceutical cardioactive agent
• Ouabain octahydrate has also been found to induce cytotoxic effects through a steroidal signal transduction pathway, in laboratory preparations

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 11018-89-6
Molecular Formula C29H44O12·8H2O
Molecular Weight (g/mol) 728.78
MDL Number MFCD00149240
InChI Key TYBARJRCFHUHSN-DMJRSANLSA-N
Synonym ouabain octahydrate, strophantine octahydrate, quabain octahydrate, ouabain usp, penta a phenanthren-17-yl-2h-furan-5-one;octahydrate, gamma-strophanthin, 3-1r,3s,5s,8r,9s,10r,11r,13r,14s,17r-1,5,11,14-tetrahydroxy-10-hydroxymethyl-13-methyl-3-2r,3r,4r,5r,6s-3,4,5-trihydroxy-6-methyloxan-2-yl oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1h-cyclo, prestwick_370, acocantherine;g-strophanthin
PubChem CID 6364534
IUPAC Name 3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one;octahydrate
SMILES CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O

Specifications

Melting Point 260.0°C
Color White
Infrared Spectrum Authentic
Assay Percent Range 95% min. (HPLC)
Packaging Glass bottle
Quantity 250 mg
Beilstein 15, V,5, 123
Merck Index 14, 6901
Specific Rotation Condition − 33.00 (20.00°C c=1,H2O,on dry subs.)
Specific Rotation − 33.00
Solubility Information (1% in water) Clear colorless
Formula Weight 728.78
Percent Purity 96%
Physical Form Crystalline Powder
Chemical Name or Material Ouabain octahydrate
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Safety and Handling

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Product Identifier
  • Ouabain octahydrate
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 1
  • Acute toxicity Category 3
  • Specific target organ toxicity after repeated exposure Category 2
 Hazard Statement
  • H300-Fatal if swallowed.
  • H331-Toxic if inhaled.
  • H373-May cause damage to organs.
 Precautionary Statement
  • P260-Do not breathe dust/fume/gas/mist/vapours/spray.
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P311-Call a POISON CENTER/doctor/ .
 Supplemental information
  • MIXTURE LIST-Contains : Ouabain octahydrate

RUO – Research Use Only

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