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MLH1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11697-1-AP-20UL
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Description
This antibody is specific to MLH1.
MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.Specifications
| MLH1 | |
| Polyclonal | |
| Unconjugated | |
| MLH1 | |
| COCA2, FCC2, hMLH1, HNPCC, HNPCC2, MLH1, MutL protein homolog 1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 17350, 4292, 81685 | |
| -20°C | |
| Liquid |
| Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.4 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P40692, P97679, Q9JK91 | |
| Mlh1 | |
| MLH1 Fusion Protein Ag2319 | |
| 20 μL | |
| Primary | |
| Rat, Mouse, Human | |
| Antibody | |
| IgG |
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