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L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.
52.86 € - 453.26 €
Chemical Identifiers
| CAS | 133073-73-1 |
|---|---|
| Molecular Formula | C20H22N8O5 |
| Molecular Weight (g/mol) | 454.45 |
| MDL Number | MFCD00150847 |
| InChI Key | FBOZXECLQNJBKD-UGPWUYPHNA-N |
| Synonym | l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrateShow More |
| PubChem CID | 45157423 |
| IUPAC Name | (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate |
| SMILES | CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
| Product Code | Brand | Quantity | Packaging | Price | Quantity & Availability | ||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Packaging | Price | Quantity & Availability | ||||
|
10002690
|
Thermo Scientific Acros
208100250 |
25 mg | Glass Bottle |
52.86 €
25mg |
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|
10491631
|
Thermo Scientific Acros
208101000 |
100 mg | Glass Bottle |
130.65 €
100mg |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
10066203
|
Thermo Scientific Acros
208105000 |
500 mg | Glass Bottle |
453.26 €
500mg |
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Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
- It has tumoricidal activity
Applications
- L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
- It can be used in anti-tumor studies
- It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
- It can also inhibit production of pro-inflammatory cytokines
Chemical Identifiers
| 133073-73-1 | |
| 454.45 | |
| FBOZXECLQNJBKD-UGPWUYPHNA-N | |
| 45157423 | |
| CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=OShow More |
| C20H22N8O5 | |
| MFCD00150847 | |
| l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrateShow More | |
| (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrateShow More |
Specifications
| 133073-73-1 | |
| Yellow to Orange | |
| 98.5% min. (HPLC) | |
| MFCD00150847 | |
| + 21.5 | |
| Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a | |
| CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O | |
| 454.45 | |
| 454.44 | |
| Crystalline Powder |
| 195°C | |
| Authentic | |
| C20H22N8O5 | |
| 14, 5985 | |
| l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate | |
| FBOZXECLQNJBKD-UGPWUYPHNA-N | |
| (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate | |
| 45157423 | |
| 99% | |
| L(+)-Amethopterin hydrate |
Safety and Handling
GHS H Statement:
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.
GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
GHS Signal Word: Danger
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
- L(+)-Amethopterin hydrate
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 3
- Germ cell mutagenicity Category 1B
- Reproductive toxicity Category 1A
Hazard Statement
- H360D-May damage the unborn child.
- H340-May cause genetic defects.
- H301-Toxic if swallowed.
Precautionary Statement
- P201-Obtain special instructions before use.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P308+P313-IF exposed or concerned: Get medical advice/attention.
RUO – Research Use Only
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Product Title
L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals