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IL5RA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12655-1-AP-150UL
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Description
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cellreplacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R),which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain,constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the ytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.Specifications
| IL5RA | |
| Polyclonal | |
| Unconjugated | |
| IL5RA | |
| CD125, CDw125, HSIL5R3, IL 5 receptor subunit alpha, IL 5R alpha, IL 5R subunit alpha, IL 5RA, IL5R, IL5RA, interleukin 5 receptor, alpha | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 114103, 16192, 3568 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.13 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P21183, Q01344 | |
| Il5ra | |
| IL5RA Fusion Protein Ag3358 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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