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Invitrogen™ Ambion™ mirVana™ miRNA Inhibitor, let-7c positive control

miRNA inhibitors are small, chemically modified single-stranded RNA molecules designed to specifically bind to and inhibit endogenous miRNA molecules and enable miRNA functional analysis by down-regulation of miRNA activity.

Brand:  Invitrogen™ 4464081

812.04 EUR valid until 2024-09-28
Use promo code "21626" to get your promotional price.


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Product Code. 13325384

  • 1218.00 € / 20nmol

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To receive the discount customers must purchase three of the same product at list price in a single order to receive 33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21626” to get your promotional price

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Description

Description

miRNA inhibitors are small, chemically modified single-stranded RNA molecules designed to specifically bind to and inhibit endogenous miRNA molecules and enable miRNA functional analysis by down-regulation of miRNA activity.

We have now released the second generation of miRNA inhibitors, mirVana™ miRNA Inhibitors, which:

  • Display better potency than lead competitor's product
  • Offer maximum and consistent effect in vitro at low miRNA inhibitor concentration
  • Target the most updated Sanger content
  • Can be used in vitro and in vivo, offering consistency throughout your entire research project
  • Are non-toxic

Positive and negative controls are also available for use along with mirVana™ miRNA Inhibitors in miRNA down-regulation experiments.

mirVana™ miRNA Inhibitor let-7c Positive Control

The mirVana™ miRNA Inhibitor let-7c Positive Control is intended for use as a positive control for mammalian cell culture experiments using mirVana™ miRNA Inhibitors. Endogenous let-7c miRNA has been shown to negatively regulate HMGA2 mRNA in cultured cells. HMGA2 is a ubiquitously expressed, nonhistone, chromatin protein that can modulate gene expression through changes in chromatin architecture. let-7c miRNA down-regulates levels of HMGA2 mRNA. When transfected into human and mouse cell lines, let-7c miRNA inhibitor blocks endogenous let-7c miRNA, resulting in increased levels of HMGA2 mRNA. Thus, let-7c miRNA inhibitor activity can be monitored in human or mouse cells using real-time reverse transcription PCR (RT-PCR) to detect HMGA2 mRNA.

First Generation Inhibitor Controls

Our first-generation miRNA inhibitors (and controls), Ambion™ Anti-miR™ miRNA Inhibitors, have lower specificity and potency, plus a lower strand specificity compared to the new mirVana™ miRNA Inhibitors. These first-generation inhibitors are recommended for completing ongoing in vitro miRNA studies. For new studies or in vivo studies, we highly recommend our new mirVana™ miRNA Inhibitors and their corresponding controls.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Store at or below -20°C. Do not store in a frost-free freezer.
Positive Control
miRNA & Non-Coding RNA Analysis
mirVana™
Purified
Room Temperature
mirVana™ miRNA Inhibitor, 20nmol, Liquid, Unconjugated Dye, Anti-miRNA RNAi Type, Positive Control Type, Used for miRNA and Non-Coding RNA Analysis, Purified Purification, –20°C Storage Temperature, For Research Use Only
miRNA Inhibitor
Unconjugated
miRNA Inhibitor
20 nmol
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For Research Use Only. Not for use in diagnostic procedures.