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Proteintech HumanKine™ recombinant human IGF-I protein

HumanKine™ recombinant protein

Brand:  Proteintech HZ-1322-1000UG

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Product Code. 17680087

  • 165.00 € / 1000µg

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Description

Description

The Insulin like growth factor-1, also known as Somatomedin-C is a growth factor which is structurally related to insulin and is an important regulator of growth and differentiation in various tissues and cell systems. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C-terminal propeptide. The two precursor isoforms are differentially expressed by various tissues. The proteolytic cleavage of the N- and C-terminal regions results in the mature IGF-1 protein which is identical between isoforms. IGF-1 binds to IGF-1 receptor and induces receptor autophosphorylation. This further phosphorylates Insulin receptor substrate -1 (IRS-1) and activates various downstream signaling pathways including the PI3-AKT, MAPK etc. (PMID: 17354613, 17113337, 29535161)
Specifications

Specifications

P05019
3479
1000 μg
Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.)
Human
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Lyophilized
1 x PBS pH 7.4
10 kDa
HEK293
<1 EU/μg
Recombinant
2-14 ng/mL EC50
>95%
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