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Proteintech HumanKine™ recombinant human IGF-I protein
HumanKine™ recombinant protein
Brand: Proteintech HZ-1322-1000UG
This item is not returnable.
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Description
The Insulin like growth factor-1, also known as Somatomedin-C is a growth factor which is structurally related to insulin and is an important regulator of growth and differentiation in various tissues and cell systems. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C-terminal propeptide. The two precursor isoforms are differentially expressed by various tissues. The proteolytic cleavage of the N- and C-terminal regions results in the mature IGF-1 protein which is identical between isoforms. IGF-1 binds to IGF-1 receptor and induces receptor autophosphorylation. This further phosphorylates Insulin receptor substrate -1 (IRS-1) and activates various downstream signaling pathways including the PI3-AKT, MAPK etc. (PMID: 17354613, 17113337, 29535161)Specifications
| P05019 | |
| 3479 | |
| 1000 μg | |
| Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.) | |
| Human | |
| Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA). | |
| Lyophilized |
| 1 x PBS pH 7.4 | |
| 10 kDa | |
| HEK293 | |
| <1 EU/μg | |
| Recombinant | |
| 2-14 ng/mL EC50 | |
| >95% |