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Invitrogen™ Human LAIR1 ELISA Kit
Human LAIR1 quantitates human LAIR1 in serum, plasma, supernatant.
656.00 € - 2635.00 €
Specifications
| Accession Number | 5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; LAIR-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1 |
|---|---|
| Assay Range | 0.6 to 130 ng/mL |
| Assay Sensitivity | 0.6 ng/mL |
| Conjugate | Biotin |
| Product Type | ELISA |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17155059
|
Invitrogen™
EH291RBX5 |
5 x 96 Tests |
2635.00 €
Each |
Estimated Shipment: 27-01-2025
Log in to see stock. |
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|
17174583
|
Invitrogen™
EH291RB |
96 Tests |
656.00 €
Pack of 96 |
Estimated Shipment: 28-01-2025
Log in to see stock. |
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Description
Human LAIR1 quantitates human LAIR1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human LAIR1.
LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.Specifications
| 5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; LAIR-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1 | |
| 0.6 ng/mL | |
| ELISA | |
| Colorimetric Microplate Reader | |
| LAIR1 | |
| <10% | |
| HRP | |
| Supernatant, 50 μL; Serum, 50 μL; Plasma, 50 μL | |
| LAIR1 (CD305) | |
| 4 hr 45 min |
| 0.6 to 130 ng/mL | |
| Biotin | |
| Plasma, Serum, Supernatant | |
| Q6GTX8 | |
| <12% | |
| Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers | |
| Research Use Only | |
| 2°C to 8°C | |
| 1 hr 20 min |
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