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Invitrogen™ Human EN-RAGE/S100A12 ELISA Kit
Human EN-RAGE/S100A12 quantitates human EN-RAGE/S100A12 in serum, plasma, supernatant.
Brand: Invitrogen™ EH170RBX5
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Description
Human EN-RAGE/S100A12 quantitates human EN-RAGE/S100A12 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human EN-RAGE/S100A12.
S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
Specifications
| CAAF1; CAGC; Calcitermin; calcium-binding protein in amniotic fluid 1; calgranulin C; calgranulin-C; CGRP; EN RAGE; ENRAGE; EN-RAGE; Extracellular newly identified RAGE-binding protein; Migration inhibitory factor-related protein 6; MRP6; MRP-6; Neutrophil S100 protein; p6; Protein S100 A12; Protein S100-A12; S100 calcium binding protein A12; S100 calcium-binding protein A12; S100 calcium-binding protein A12 (calgranulin C); S100A12 | |
| 0.82 ng/mL | |
| ELISA | |
| Colorimetric Microplate Reader | |
| S100A12 | |
| <10% | |
| HRP | |
| Research Use Only | |
| 2°C to 8°C | |
| 1 hr 20 min |
| 0.82 to 200 ng/mL | |
| Biotin | |
| Plasma, Serum, Supernatant | |
| P80511 | |
| <12% | |
| Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers | |
| 5 x 96 Tests | |
| Supernatant, 50 μL; Plasma, 50 μL; Serum, 50 μL | |
| S100A12 | |
| 4 hr 45 min |
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