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Guanidine Hydrochloride, Ultra Pure grade, MP Biomedicals

Product Code. 11461682

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Quantity:

100 g

1 kg

This item is not returnable. View return policy

Description

Guanidine Hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of proteins
This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies
This can be used as the first step in refolding proteins or enzymes into their active form
Urea and dithiothreitol (DTT) may also be necessary
Guanidine HCl is used in the isolation of RNA to dissociate the nucleoprotein into its nucleic acid and protein moieties
It is an inhibitor of RNase
Highly concentrated (6 - 8 M) Guanidine HCl solutions are used to denature native globular proteins
It apparently disrupts hydrogen bonds which hold the protein in its unique structure; however, there also is evidence suggesting that guanidine hydrocholoride may disrupt hydrophobic interactions by promoting the solubility of hydrophobic residues in aqueous solutions

CAS	50-01-1
Molecular Formula	CH6ClN3
Molecular Weight (g/mol)	95.53
MDL Number	MFCD00013026
InChI Key	PJJJBBJSCAKJQF-UHFFFAOYSA-N
Synonym	guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
PubChem CID	5742
ChEBI	CHEBI:32735
IUPAC Name	guanidine;hydrochloride
SMILES	C(=N)(N)N.Cl

Melting Point	180°C to 190°C
Color	White
Linear Formula	CH5N3·HCl
Quantity	1 kg
Solubility Information	Soluble in water (6 M - clear, colorless solution).
Formula Weight	95.53
Percent Purity	≥99%
Grade	Ultra Pure
Physical Form	Crystalline Powder
Chemical Name or Material	GUANIDINE HYDROCHLORIDE

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Hazard Category

Hazard Statement

Precautionary Statement

P101-If medical advice is needed, have product container or label at hand.
P102-Keep out of reach of children.
P103-Read label before use.
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P321-Specific treatment (see on this label).
P362-Take off contaminated clothing.
P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
P501-Dispose of contents/container to in accordance with local/regional/national/international regulations.

Supplemental information