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BD Caspase-8

Play role in apoptosis induced by death receptors

Brand:  BD 556481

Product Code. 15808718

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Description

Description

Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. elegans death gene that is required for normal apoptosis during development

  • Fas and tumor necrosis factor receptor type 1 (TNFR1)
  • One of its substrates is poly (ADP ribose) polymerase (PARP)
  • PARP is an enzyme that is involved in DNA repair and genomic maintenance
  • Cleaves PARP from its 116kDa form to 85kDa residual fragment
  • The cleavage site in PARP is C-terminal to Asp-216
  • Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
  • Format: Purified

Fluorescence quantitation

TRUSTED_SUSTAINABILITY
Specifications

Specifications

0.2mg/mL
Human Caspase-8 Protease Recombinant Protein
-80°C
Recombinant
Fluorescence Quantitation
5μg
Human
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