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  7. 1-Methylpiperazine, 98+%, Thermo Scientific Chemicals

1-Methylpiperazine, 98+%, Thermo Scientific Chemicals

Product Code. 11439802
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Quantity:
100 mL
500 mL
2500 mL
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Description

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Solubility
Miscible with water and methanol.

Notes
Hygroscopic. Moisture sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 109-01-3
Molecular Formula C5H12N2
Molecular Weight (g/mol) 100.165
MDL Number MFCD00005966
InChI Key PVOAHINGSUIXLS-UHFFFAOYSA-N
Synonym n-methylpiperazine, piperazine, 1-methyl, 4-methylpiperazine, 1-methyl-piperazine, n-methyl piperazine, 1-methyl piperazine, methylpiperazine, n-methyl-piperazine, n-methylpiperazin, 1-methylpyperazine
PubChem CID 53167
IUPAC Name 1-methylpiperazine
SMILES CN1CCNCC1

Specifications

Melting Point -6°C
Density 0.903
Boiling Point 137°C to 139°C
Flash Point 34°C (93°F)
Odor Amine-like
Refractive Index 1.4655
Quantity 500 mL
UN Number UN2734
Beilstein 102724
Sensitivity Air Sensitive
Solubility Information Miscible with water and methanol.
Formula Weight 100.17
Percent Purity ≥98%
Chemical Name or Material 1-Methylpiperazine
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Safety and Handling

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Product Identifier
  • 1-Methylpiperazine
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 1
  • Flammable liquid Category 3
  • Skin corrosion/irritation Category 1 B
 Hazard Statement
  • H226-Flammable liquid and vapour.
  • H312-Harmful in contact with skin.
  • H314-Causes severe skin burns and eye damage.
  • H318-Causes serious eye damage.
  • H332-Harmful if inhaled.
 Precautionary Statement
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
 Supplemental information
  • MIXTURE LIST-Contains : 1-Methylpiperazine

RUO – Research Use Only

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